A truck carrying white wine from South Australia's Barossa caught alight while driving along the highway overnight.
Five fire crews with 25 firefighters rushed to the Dukes Highway outside Cooke Plains after the B-double truck caught ablaze.
The driver of the truck had safely gotten out of the car and detached the prime mover while flames incinerated the trailers - and the contents.
"Fire cause is believed to be a mechanical fault in one of the trailers which were both significantly impacted with damaged costs estimated at $400,000," Country Fire Service said in a statement.